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There may be increased difficulty in treating an allergic type reaction in patients on beta-blockers. Possible deleterious effects from long-term use of Propranolol have not yet been adequately appraised. This combination can cause severely high blood pressure and heart failure. Propranolol exerts ant arrhythmic effects in concentrations producing beta-adrenergic blockade, which appears to be its principal ant arrhythmic mechanism of action.
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