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Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Individuals who have developed allergic reactions from aspirin or other NSAIDs may experience an allergic reaction to Celecoxib and should not take Celecoxib. The management of osteoarthritis, rheumatoid arthritis, acute pain, and nausea versus prescription ibuprofen and naproxen. Celecoxib differs from other NSAIDs in that it causes less inflammation and ulceration of the stomach and intestine and does not interfere with the function of the blood platelets and, as a result, does not reduce clotting and lead to increased bleeding like other NSAIDs. Celecoxib is a nonsteroidal anti-inflammatory drug that is used to decrease growths found in the intestines of persons with a family history of this condition. Celecoxib is used for the relief of acute pain and the pain of menstrual cramps.